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Spyre Therapeutics, Inc.
SYRE · Nasdaq · ·
Next earnings: November 3, 2026
$84.70-1.3%Sep 29 close
- 1M
- -6.3%
- 6M
- +86.5%
- 1Y
- +405.4%
- 5Y
- -56.7%
SYRE · Nasdaq · ·
Next earnings: November 3, 2026
$84.70-1.3%Sep 29 close
Spyre Therapeutics, Inc. is the 38th largest of 361 graded companies. Showing 5 of them, including SYRE itself. 235 more are in this industry but have no grade yet, so they are left out rather than shown blank.
| Company | Grade | Market value | Revenue | Profit margin | Free cash flow | Price to earnings |
|---|---|---|---|---|---|---|
| vTv Therapeutics Inc.VTVT | D- | — | $36.8M | -12.9% | -$25.3M | — |
| Crinetics Pharmaceuticals, Inc.CRNX | D- | — | $42.2M | -1,189.9% | -$425.2M | — |
| Barinthus Biotherapeutics plcBRNS | D- | — | $0.00 | — | -$26.4M | — |
| Vertex Pharmaceuticals Inc. / MAVRTX | B+ | $133.5B | $12.6B | 35.0% | $3.8B | 30.68 |
| Spyre Therapeutics, Inc.SYRE | F | $7.5B | $0.00 | — | -$157.4M | — |
A blank price-to-earnings means a loss, not a missing figure — the ratio has no meaning when there are no earnings to divide by, and printing a negative one would make the least profitable company look the cheapest.
Grades are trailing twelve months from each company’s own SEC filings, so they move only when a company files. Every column is computed by the same code that graded Spyre Therapeutics, Inc. on the overview — nothing here comes from a data vendor’s own ratios.
Industry membership is not a judgement about how similar two businesses are. It groups companies by what they are classified as, which is a starting point for comparison rather than a claim that they compete.
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Graded on the same five checks, from their own SEC filings.